Moreover, these effects were heritable; FKBP5 methylation was reduced in the offspring of Holocaust survivors (Bierer et al., 2020), paternal PTSD was associated with greater methylation of the NR3C1 gene in blood samples obtained from offspring (Yehuda et al., 2014), and PTS-induced alterations to DNA methylation of NR3C1 and FKBP5 in paternal sperm were linked to mental health diagnoses in offspring (Mehta et al., 2019). The gene discussed is FKBP5; the disease is post-traumatic stress disorder.