Offspring born to fathers who experienced trauma exhibited changes to nociceptive sensitivity, social and anxiety-like behaviour, as well as changes in expression of 5HT1A, 5HT2A, Comt, Dnmt3a, Drd2, FKBP5, NR3C1, Maoa, and Mecp2 in the adrenal gland, hippocampus, hypothalamus, prefrontal cortex, and thalamus. This evidence concerns the gene HTR2A and Anxiety.