Offspring born to fathers who experienced trauma exhibited changes to nociceptive sensitivity, social and anxiety-like behaviour, as well as changes in expression of 5HT1A, 5HT2A, Comt, Dnmt3a, Drd2, FKBP5, NR3C1, Maoa, and Mecp2 in the adrenal gland, hippocampus, hypothalamus, prefrontal cortex, and thalamus. The gene discussed is COMT; the disease is Anxiety.