However, statistically significant relationships were identified between tumor budding and perineural invasion (p = 0.015), lymphovascular invasion (p = 0.005), T stage (p < 0.001), N stage (p < 0.001), prognostic stage (p < 0.001), surgical margin positivity (p = 0.003), differentiation grade (p < 0.001), and E‐cadherin pattern (p < 0.001). The gene discussed is CDH1; the disease is neoplasm.