In contrast, the inflammatory factors in the serum of rats in the GBXZF group were significantly reduced compared with those in the NSG group, suggesting that GBXZF could ameliorate renal fibrosis by upregulating the PI3K/AKT inflammatory pathway, which was associated with a reduction in the levels of inflammatory factors in the blood (Figure 6F,G). Here, AKT1 is linked to renal fibrosis.