IL1B and obesity due to melanocortin 4 receptor deficiency: As obesity is a state of IR, adipose tissue can secrete tumor necrosis factor (TNF‐α), interleukin‐6 (IL‐6), interleukin‐1β (IL‐1β) and other substances (Saltiel and Olefsky 2017; Siwicki et al. 2016).