Moreover, a novel RNA-binding protein-dependent regulatory axis was identified, where circRNA Cwc27 interacted with purine-rich element-binding protein α and trapped it in the cytoplasm, resulting in its inactivation and transcriptional upregulation of amyloid precursor protein and other Alzheimer’s disease-related genes (Song et al., 2022). Here, APP is linked to early-onset autosomal dominant Alzheimer disease.