In contrast, circRNA NF1-419 increased autophagy in astrocytes via PI3K-I/Akt-AMPK-mTOR and PI3K-I/Akt–mTOR signaling pathways and affected inflammatory mediators and delayed the development of dementia in an animal model of Alzheimer’s disease (Diling et al., 2019). Here, AKT1 is linked to dementia.