In contrast, circRNA NF1-419 increased autophagy in astrocytes via PI3K-I/Akt-AMPK-mTOR and PI3K-I/Akt–mTOR signaling pathways and affected inflammatory mediators and delayed the development of dementia in an animal model of Alzheimer’s disease (Diling et al., 2019). This evidence concerns the gene AKT1 and early-onset autosomal dominant Alzheimer disease.