MAPT and early-onset autosomal dominant Alzheimer disease: Ultimately, amyloid-tau protein synergy, with the help of neuroinflammatory factors (Sekeljic et al., 2012; Radenovic et al., 2020), leads to synaptic dysfunction and neuronal death and post-ischemic neurodegeneration, identical to Alzheimer’s disease (Pluta et al., 2009; Swardfager et al., 2014; Guan et al., 2022; Pluta, 2024; Ebrahimi et al., 2025; Pluta, 2025).