MAPT and Alzheimer disease: ST has been successfully used in the context of AD-like mouse models and human brains (Chen et al., 2022; Chen et al., 2020; Choi et al., 2023; Das et al., 2024; Mathys et al., 2019; Navarro et al., 2020; Yu et al., 2024; Zou et al., 2024) but so far it has not been applied to analyze the influence of tau, and its pathological forms, on RNA expression in a spatial context.