Notably, TTR has been linked to AD, as it binds to amyloid beta peptide (Abeta, Aβ), sequesters it, and prevents its aggregation (Buxbaum, 2023; Buxbaum et al., 2008; Cascella et al., 2013; Ciccone et al., 2020; Costa et al., 2008; Gonzalez-Marrero et al., 2015; Iqbal, 2018; Li et al., 2013; Liz et al., 2020; Nilsson et al., 2018; Schwarzman et al., 1994; Ueda, 2022; West et al., 2021). The gene discussed is APP; the disease is Alzheimer disease.