MAPT and Alzheimer disease: Figures 3A–C displays the expression pattern and transcript levels of Ttr from Tau22 mice from the hippocampus and ventricles, whereas Figures 3D–F show similar results from the TauKO mice. The plots show the mean and median values to facilitate easier comparison. The RNA plots of Ttr expression are overlaid on the tissue slices in Figure 3G for Tau22 mice and Figure 3H for TauKO mice. Ttr is an RNA coding for an extracellular chaperone deregulated in AD but there is little known about a regulatory relationship between tau and TTR protein.