Garcia-Sanchez et al. (29) investigated the impact of SIRPα genotype on innate allorecognition via the SIRPα–CD47 axis in HLA-identical kidney transplant recipients and reported a significantly higher incidence of histological peritubular capillaritis, without a corresponding increase in rejection, in SIRPα-mismatched pairs. This evidence concerns the gene SIRPA and medical procedure.