Pathogenic variants in the EIF2B5 gene, which encodes the epsilon subunit of the eukaryotic translation initiation factor 2B (eIF2B), are associated with autosomal recessive leukodystrophy with VWM, which is frequently—but not invariably—accompanied by ovarian disorder in females (Ibitoye et al., 2016). This evidence concerns the gene EIF2B1 and leukoencephalopathy with vanishing white matter.