,83,93,95,99,101,104, 105, 106, 107, 108, 109, 110 In melanoma, several studies consistently reported an increased clonality in blood or tumor from patients benefiting from anti-PD-1/anti-PD-L1 therapy, either alone or combined with anti-CTLA-4.82 Here, PDCD1 is linked to neoplasm.