The selected predictors included clinical and demographic variables such as alcohol consumption, urine cytology, history of prior surgery, duration of smoking and drinking, and blood pressure, as well as histopathological features (e.g., vascular and perineural invasion, tumor stage and grade) and molecular markers (e.g., Uroplakin III, GATA3, CK20, AR, PD-L1, and HER2 expression). The gene discussed is ERBB2; the disease is neoplasm.