We analyzed the association of RNF220 with various tumor biological functions using single-cell RNA sequencing datasets from the CancerSEA database (http://biocc.hrbmu.edu.cn/CancerSEA/) (AML datasets: Exp0047, Exp0048, Exp0049; ALL dataset: EXP0046; CML dataset: EXP0050). The gene discussed is RNF220; the disease is neoplasm.