Members of the DLX family exhibit diverse functions in tumors, including DLX4, which is highly expressed in non-small cell lung cancer and promotes cell proliferation and cell cycle progression via the YB-1/CKS2 axis (18), DLX5 activates the NOTCH pathway to enhance invasiveness in osteosarcoma (19), and DLX3 may act as a tumor suppressor in cutaneous squamous cell carcinoma by inhibiting the EGFR-ERBB2 pathway (20). This evidence concerns the gene DLX5 and osteosarcoma.