On univariate Cox analysis (Table 2), several factors were significantly associated with poorer OS: advanced AJCC stage (III vs. II, HR ≈2.33, p < 0.001), higher T category (T3/T4 vs. T1/T2, p < 0.001), lymph node metastasis (N1 vs. N0, HR ≈2.32, p < 0.001), elevated preoperative CA19–9 and CEA (both p < 0.001), capsular invasion (p = 0.021), microvascular invasion (HR ≈1.88, p < 0.001), perineural invasion (HR ≈1.33, p = 0.043), and extrahepatic extension (HR ≈1.44, p = 0.026). The gene discussed is CEACAM5; the disease is metastatic malignant neoplasm in the lymph nodes.