EGFR mutations represent the most prevalent genetic alterations in lung cancer among Asian populations, with an overall mutation rate ranging from 20% to 76% (2, 20).The prevalence of EGFR mutations is significantly increased in specific subpopulations, particularly among females (female vs. male: 43.7% vs. 24.0%; OR 2.7, 95% CI 2.5-2.9) and never-smokers (never-smokers vs. former/current smokers: 49.3% vs. 21.5%; OR 3.7, 95% CI 3.4-4.0), compared to other demographic groups (2, 3, 20). The gene discussed is EGFR; the disease is lung cancer.