Meanwhile, the core targets were subjected to the KEGG pathway enrichment analysis to screen for pathways with q<0.05, and a total of twenty were obtained, such as the MicroRNAs in cancer, the Thyroid hormone signaling pathway, the Neurotrophin signaling pathway, the Hippo signaling pathway, the FoxO signaling pathway, ErbB signaling pathway (Supplementary Figure S2).In the down-regulation of miRNA target gene, the main results are the regulation of RNA splicing, cytoplasmic stress granule, and monooxygenase activity (Supplementary Figure S3). This evidence concerns the gene BDNF and cancer.