According to meta-analysis, compared with the control group, acupuncture significantly reduced IL-1β (SMD: −1.62, 95% CI: −1.93, −1.31), IL-6 (SMD: −1.89, 95% CI: −2.51, −1.26), and TNF-α in depression animals (SMD: −2.09, 95% CI: −2.83, −1.34) and improved IL-4 (SMD: 1.01, 95% CI:0.35, 1.67), IL-10 (SMD:0.77, 95% CI:0.26, 1.28), body weight (SMD:1.69, 95% CI: 1.23, 2.15), crossing numbers (SMD: 1.74, 95% CI: 1.31, 2.17), and rearing numbers (SMD: 1.77, 95% CI: 1.16, 2.39). The gene discussed is IL6; the disease is major depressive disorder.