HDAC1 and early-onset autosomal dominant Alzheimer disease: Mechanistic studies indicate that HDAC1 deficiency leads to the accumulation of DNA damage and cognitive decline in mouse brains, while HDAC1 activators can enhance cognitive function in aged mice and Alzheimer’s disease model mice by facilitating the recruitment of DNA damage repair enzymes, such as OGG1 (Pao et al., 2020).