Transcription 3 activator and signal transducer may regulate the expression of NEAT1, and downstream gene transcription is affected by the altered expression of NEAT1 epigenetically during Alzheimer’s disease and HSV-1 (herpes simplex virus-1), suggesting the function of NEAT1 as an effector and stress sensor, in addition to the target-genes expression, which is influenced by the molecular mechanism of NEAT (Wang Z. et al., 2020). This evidence concerns the gene NEAT1 and early-onset autosomal dominant Alzheimer disease.