The pathogenesis of glioma often involves dysregulated signaling in key oncogenic pathways, such as constitutive PI3K/AKT activation, EGFR amplification/overexpression, and other aberrant growth factor signals (Woo et al., 2020; Zhao et al., 2021; The Cancer Genome Atlas Research Network, (2008)). Here, AKT1 is linked to glioma.