The Venn diagram in Figure 1G shows the intersection of the top 15 feature genes from the three models(GBM, NNET, RF), among which 8 genes (EIF2AK2, PPARG, BACE1, ESR1, GSK3B, ACE, CASP3, and MAPK14) were highly weighted in all three algorithms, suggesting that these genes may be key target proteins for MGD in intervening AD. Here, ESR1 is linked to Alzheimer disease.