Compared with healthy controls, 7 core genes in the hippocampus of AD patients (EIF2AK2, BACE1, ESR1, GSK3B, ACE, CASP3, and MAPK14) were significantly upregulated, with statistically significant differences (p < 0.05), except for PPARG (Supplementary Figure S1). Here, ACE is linked to Alzheimer disease.