CASP3 and Alzheimer disease: In the simulation, MOL000830 and 1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE (an inhibitor of CASP3) shared the same binding sites TYR-204, TRP-206, and PHE-256, indicating that MOL000830 can inhibit CASP3 through the same competitive inhibition, exerting anti-AD effects.