CASP3 and Alzheimer disease: The roles of these targets in AD pathogenesis include: EIF2AK2, involved in cellular stress response and protein synthesis regulation (Feng et al., 2025), BACE1, closely related to Aβ peptide production (Kapasi et al., 2021), and CASP3, playing a key role in cell apoptosis (Feng et al., 2025).