The top 10 genes most strongly correlated with IDD were CHST3, SOX5, SPOCK2, SMAD3, FGFR3, C6orf106, GFPT1, TWIST1, ASCC1, IGFBP3 (Figure 2 and Supplementary Data 2). This evidence concerns the gene TWIST1 and intervertebral disk degenerative disorder.