Our analysis indicates that even in non-obese populations, the association between TG/HDL-c and CKD remains significant (OR = 1.1660, 95% CI: 1.0810–1.2577), which supports that lipid toxicity may function independently of obesity; (3) Endothelial dysfunction and vascular injury: dyslipidemia triggers inflammatory cytokine production and adipokine imbalance (increased leptin, decreased adiponectin), which leads to endothelial dysfunction and vascular injury (72). This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.