When individuals with diabetes were excluded from the analysis, the results demonstrated that TG/HDL-c ratio remained significantly and positively associated with CKD risk (OR = 1.1848, 95% CI: 1.1230–1.2500) after adjusting for age, sex, BMI, LDL-c, ALT, AST, GGT, smoking, drinking, hypertension, and tumor history. The gene discussed is GPT; the disease is hypertensive disorder.