Specifically, SIRT1 inhibits the activation of the NLRP3 inflammasome and the STING pathway through a Rab7-dependent late endosome-mitophagy pathway, thereby reducing sepsis-related acute lung injury (101); SIRT3 mediates melatonin-induced deacetylation of TFAM, promotes mitophagy, and improves sepsis-induced acute kidney injury (102). The gene discussed is SIRT3; the disease is Sepsis.