Regulatory B cells (Bregs; CD24highCD38high) produce IL-10 and TGF-β, dampening CD8+ T cell responses and promoting tumor immune evasion in CMS4 CRC (Schwartz et al., 2016; Sarvaria et al., 2017; Liu et al., 2020; Catalán et al., 2021; Tan et al., 2022). The gene discussed is CD8A; the disease is colorectal carcinoma.