In CRC, the ECM is composed of structural proteins such as type I–IV collagens (COL1A1, COL3A1, and COL4A1), fibronectin (FN1), lumican (LUM), and osteonectin (SPARC) (Yue, 2014; Henke et al., 2020; Kim M.-S. This evidence concerns the gene SPARC and colorectal carcinoma.