LDLR antibodies or LDLR knockout have been shown to inhibit the infection of diverse viruses, including human viruses [SARS-CoV-2 (Uppal et al., 2023), HBV (Li and Luo, 2021), and RSV (Chen et al., 2024)], animal viruses [PRV (Ma Y. X. et al., 2024)], and zoonotic agents [JEV (Huang et al., 2021) and CCHFV (Ritter et al., 2024)]. Here, LDLR is linked to infection.