For example, a CCR7low Treg subset has been implicated in dysfunctional interferon responses in systemic lupus erythematosus (SLE)13; αβ T cells lacking CCR7 are enriched in coronary plaques14; and CCR7 expression in peripheral CD4+T cells has been linked to disease activity in rheumatoid arthritis and active SLE.15 This evidence concerns the gene CD4 and rheumatoid arthritis.