Furthermore, high concentrations of inflammatory markers have been seen in uncontrolled DM and those developing complications.47 Systemic inflammation is linked with ineffective maturation of erythrocytes, reduced iron metabolism and decreased cell survival which cause an increase in RDW.48,49 A positive association between inflammatory markers like interleukin-6, C-reactive protein and erythrocyte sedimentation rate has been seen with increased RDW.50 The gene discussed is IL6; the disease is diabetes mellitus.