CRP and Increased total leukocyte count: Based on new or persistent infiltrations on chest x-ray in combination with leukocytosis with left shift or leukocytopenia, at least 50% increase of C-reactive protein compared to baseline, hypo- (<36.50C) or hyperthermia (>38.5 o C), cough with purulent sputum or characteristically rattling noises on auscultation