The third available study on pyroptosis encompassed a STZ-induced DKD model with 7 treatment arms: wild-type control group (WT-NC), a diabetic C57BL/6J group, an ApoE-/- group, a diabetic ApoE-/- group and three ApoE-/- groups featuring mice with DM treated with liraglutide, loxenatide or insulin (38). Here, APOE is linked to diabetic kidney disease.