As a result,VEGFA’s downstream signaling activation might be lost, leadingto impaired angiogenesis, increased endothelial cell death, and imbalancedvascular function. Multiple studies havepreviously reported that mutations in the VEGFA dimer protein areassociated with several diseases, like autoimmune disease, recurrent spontaneous miscarriage, necrotizing enterocolitis, microvascular complications of diabetes, metabolic syndrome, polycysticovary, and cancers. This evidence concerns the gene VEGFA and diabetes mellitus.