IAPP and type 2 diabetes mellitus: Thesechanges, driven by yet unidentified factors, cause amylin to transitionfrom a soluble to an insoluble form, leading to the accumulation ofamyloid deposits, which are critical pathological markers in the pancreasfor type 2 diabetes (T2D)., Understanding factorsassociated with amylin conformational changes could lead to the developmentof therapeutic strategies to prevent the formation of insoluble amyloiddeposits.−, ,