The analysis showed that the differentially expressed genes between the DSS‐induced colitis model group and the EcN‐T treatment group were enriched in 10 key pathways, including cell adhesion molecules, TNF signaling pathway, IBD, HIF‐1 signaling pathway, Nuclear Factor kappa‐light‐chain‐enhancer of Activated B Cells (NF‐kB) signaling pathway, tight junction, glycolysis/gluconeogenesis, Toll‐like receptor signaling pathway, AMP‐activated Protein Kinase (AMPK) signaling pathway, and Mechanistic Target of Rapamycin (mTOR) signaling pathway. This evidence concerns the gene HIF1A and colitis.