Similarly, in tumor models, tumor‐associated neutrophils upregulate GZB when stimulated with a cytokine mix (IL‐2, IL‐12, IL‐21) alone or combined with a TLR4 agonist, demonstrating that innate (TLR) and adaptive (cytokine) signals converge to trigger neutrophil GZB production.46 Here, TLR4 is linked to neoplasm.