Second, a T24 xenograft mouse model demonstrated that the (DOX + ISB) group exhibited greater tumor suppression than the DOX (p = 0.08) and ISB (p = 0.02) groups, with decreased Ki‐67 and Bcl‐2 expression and increased apoptosis (all p < 0.01) in an in vitro study. The gene discussed is BCL2; the disease is neoplasm.