The chromatin-modifying enzyme lysine-specific demethylase 1 (KDM1A, LSD1) colocalizes with N-Myc in the promoter regions of CDKN1A/p21 and CLU, and the use of the KDM1A inhibitor TCP can restore the expression of these two genes in MNA-NB cells (Amente et al., 2015). The gene discussed is KDM1A; the disease is neuroblastoma.