TP53 and neuroblastoma: Hua et al. regulated the expression of MYCN and SESN1 (a member of the Sestrin family and a target gene of p53) in NB cells by small interfering RNA (siRNA) or overexpression plasmids and confirmed that SESN1 is regulated by MYCN. The overexpression of SESN1 inhibited NB cell proliferation, migration, and invasion through the Toll-like receptor (TLR) signaling pathway (Hua et al., 2024).