Except for the interfering small RNA, the MYCN-targeting pyrrole-imidazole polyamide (PIP) MYCN-A3 can directly bind to and alkylate MYCN transcripts, downregulating MYCN expression and inhibiting tumor progression in the MNA-NB mouse xenograft suppressor model (Yoda et al., 2019). The gene discussed is MYCN; the disease is neuroblastoma.