Glycine decarboxylase (GLDC) is a key enzyme for glycine decomposition and is directly regulated by MYCN at the transcriptional level; its knockdown can inhibit MNA-NB cell proliferation, induce G1 phase arrest, disrupt purine metabolism, and reduce cholesterol and fatty acid levels, indicating that GLDC can be used as a therapeutic target for MNA-NB (Alptekin et al., 2019). This evidence concerns the gene MYCN and neuroblastoma.