Boboila et al. transplanted the neuroblastoma cell line 9464D derived from TH-MYCN transgenic mice into the kidneys of C57BL/6 mice to construct an MNA-NB metastasis model and confirmed that anti-PD1 antibodies combined with high-dose radiotherapy can inhibit tumor growth and enhance CD3(+) CD8(+) T-cell infiltration (Boboila et al., 2023). Here, MYCN is linked to neuroblastoma.