Recently developed AURKA-directed PROTACs have shown potent ability to degrade AURKA (Adhikari et al., 2020; Liu F. et al., 2022), disrupt its interaction with N-Myc, and reduced Aurora-A and N-Myc levels in MNA-NB cells and xenograft NB model (Nelson et al., 2025; Tang et al., 2025). This evidence concerns the gene MYCN and neuroblastoma.