Although no direct interaction between Runx1t1 and MYCN has been detected, the RUNX1T1 protein, a component of the LSD1-CoREST3-HDAC inhibitory complex, may inhibit the growth of NB with high MYCN expression by regulating chromatin accessibility through the inhibitory effect of the complex in the enhancer region (Murray et al., 2024). Here, RUNX1T1 is linked to neuroblastoma.