MYCN and neuroblastoma: Through multiomics analysis, Ding et al. reported that MYCN inhibits ELOVL fatty acid elongase 2 gene (ELOVL2) expression by recruiting PRC1 to catalyze H2AK119ub, thereby reducing docosahexaenoic acid synthesis, revealing the key role of MYCN in the regulation of lipid metabolism in neuroblastoma (Ding et al., 2019).