Affinity proteomics and molecular docking-based studies have revealed that ceftriaxone inhibits N-Myc translation by targeting DEAD-box helicase 3 X-linked (DDX3X), thereby inducing apoptosis in MYCN-amplified retinoblastoma and neuroblastoma cells (Chittavanich et al., 2024). The gene discussed is DDX3X; the disease is neuroblastoma.