POU5F1 and neuroblastoma: OCT4 is a transcription factor that regulates MYCN expression, and inhibiting its binding can induce caspase-2-dependent apoptosis in MNA-NB and reduce the high translation of HNRNPA1/PTBP1 transcripts maintained by MYCN. Targeting OCT4-MYCN binding may be an effective therapeutic strategy for MNA-NB (Nakatani et al., 2024).