Studies by Aljouda et al. have shown that the class I basic helix-loop-helix transcription factor TCF4 (also known as E2-2), a component of the super enhancer (SE)-associated transcription factor network, regulates the FOXM1/E2F-mediated gene network and synergizes with the N-Myc protein to regulate the cell cycle progression and proliferation of neuroblastoma, playing a key role in the progression of NB (Aljouda et al., 2025). This evidence concerns the gene TCF4 and neuroblastoma.