PNPLA3 and metabolic dysfunction-associated steatotic liver disease: The allele frequencies of three SNP loci (TM6SF2-Glu167Lys, PNPLA3-Ile148Met, and PNPLA3-Lys434Glu) in children and adolescents with MASLD were significantly higher than those in the healthy control group (TM6SF2-Glu167Lys: P_FDR<0.001, OR = 3.04; PNPLA3-Ile148Met: P_FDR<0.001, OR = 2.50; PNPLA3-Lys434Glu: P_FDR=0.024, OR = 1.65; Figure 1A, Table 1), suggesting an association between these three SNPs and an increased risk of MASLD.