In this study, we applied bioinformatics analyses to delineate the elevated expression of FZD5, hsa-miR-1976 and CRHR1-IT1 associated with type 2 diabetes mellitus complicated by ischemic heart disease, and evaluated whether their serum abundances could serve as noninvasive biomarker panel for early detection. This evidence concerns the gene FZD5 and coronary artery disorder.