FZD5 and type 2 diabetes mellitus: Consistent with these trajectories, FZD5, GTF2I, and hsa-miR-1976 were significantly upregulated in IHD, T2DM without complications, and T2DM+IHD versus healthy controls, whereas the overall reduction in LINC02210 across groups did not reach statistical significance (P > 0.05), as summarized in Table 3.