In this study, we applied bioinformatics analyses to delineate the elevated expression of FZD5, hsa-miR-1976 and CRHR1-IT1 associated with type 2 diabetes mellitus complicated by ischemic heart disease, and evaluated whether their serum abundances could serve as noninvasive biomarker panel for early detection. The gene discussed is FZD5; the disease is type 2 diabetes mellitus.