At the same time, PKCβ is activated by hyperglycemia and free fatty acids in pancreatic β‐cells, phosphorylating the transcription factor pancreatic and duodenal homeobox 1 (PDX‐1) (a key regulator of insulin genes), leading to a reduction in the nuclear translocation of PDX‐1 and inhibition of the transcription of insulin genes (e.g., Insulin 2) [63]. Here, PDX1 is linked to Hyperglycemia.