To determine whether these effects were specific to Fc-receptor–mediated phagocytosis, we replicated these KOs in both the parental Panc02 and the KC-806 cell line, the latter derived from the KC (KrasG12D; Cdkn2a KO) pancreatic cancer model, in which spontaneous pancreatic tumors were driven by oncogenic KrasG12D and inactivation of Cdkn2a and Smad4 (22). This evidence concerns the gene SMAD4 and familial pancreatic carcinoma.