To determine whether these effects were specific to Fc-receptor–mediated phagocytosis, we replicated these KOs in both the parental Panc02 and the KC-806 cell line, the latter derived from the KC (KrasG12D; Cdkn2a KO) pancreatic cancer model, in which spontaneous pancreatic tumors were driven by oncogenic KrasG12D and inactivation of Cdkn2a and Smad4 (22). Here, SMAD4 is linked to pancreatic neoplasm.