While Cad KO resulted in substantially slower tumor growth in both WT C57BL/6 (B6) and NSG mice, TAMs depletion by clodronate liposomes rescued the antitumor effects of Cad KO in both tumor models (Figure 2B and Supplemental Figure 3, C–E), indicating that the antitumor activity upon Cad inactivation relies on the presence of macrophages. Here, CAD is linked to neoplasm.