Depletion of TAMs using aCSF1R antibodies (Supplemental Figure 3, J and K) resulted in comparable tumor burden between control and Cad KO tumors, indicating that macrophages are crucial for controlling orthotopically inoculated Cad-KO Panc02 tumors (Figure 3, B–D, and Supplemental Figure 3L). Here, CAD is linked to neoplasm.