Mouse 4T1 cells with and without siRNA-mediated BRCA1–/– (Supplemental Figure 9B top panel) were inoculated in the fat pad of mice, Olaparib was administrated alone or in combination with GSK3Bi lithium, and the tumor volumes and weights were measured at day 14 after Olaparib (Figure 10E and Supplemental Figure 9D). The gene discussed is BRCA1; the disease is neoplasm.