Conversely, recombinant MMP‐2 has been shown to induce membrane‐bound CD100 shedding from CD8+ T cells and soluble CD100 generation, resulting in an enhancement of CD8+ T‐cell cytotoxicity toward endothelial cells in patients with acute myocardial infarction [49]. The gene discussed is SEMA4D; the disease is myocardial infarction.