Because NADPH oxidase activity can act as a signaling molecule to promote inflammatory responses and apoptosis [30, 31, 32], we propose that CD8+ T cells might trigger the activation of the NADPH oxidase‐mediated NLRP3 inflammasome, playing a role in the immune–inflammation–apoptosis axis activation during angiogenesis following ischemia. This evidence concerns the gene FMO5 and ischemia.