CD8+ T‐cell functions as an important mediator of ischemia‐induced angiogenesis via the modulation of inflammation, oxidative stress, proteolysis, and endothelial proliferation that might be mediated by the IFN‐γ/NLRp3‐caspase‐1 and VEGF/Erk1/2 axes. The gene discussed is MAPK3; the disease is ischemia.