It is thus possible that CYP17 also contributes to the increased level of DHEAS observed in the male relatives of PCOS patients [53] Lastly, DENND1A [54], YAP1 [55], ERBB3, and RAB5B [48, 56] are also implicated in PCOS, and have been shown to be involved in endocytosis, cellular trafficking calcium signaling, and the ERBB3 signaling pathway [57–59] As these genes regulate insulin metabolism and hormone production, their involvement may contribute to the higher rate of biochemical and metabolic abnormalities in both PCOS women and their male relatives. The gene discussed is INS; the disease is polycystic ovary syndrome.