Our outcomes of interest encompassed PCOS-related signs and sequelae, including continuous measures such as androgen levels (AD), body mass index (BMI), cholesterol, DHEAS, fasting blood glucose, FSH, LH, HDL, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), total testosterone, and urinary testosterone (uT), as well as categorical outcomes such as androgenetic alopecia, diabetes mellitus, hypertension, heart disease, obesity, and stroke. This evidence concerns the gene PLOD1 and polycystic ovary syndrome.