DENND1A and polycystic ovary syndrome: It is thus possible that CYP17 also contributes to the increased level of DHEAS observed in the male relatives of PCOS patients [53] Lastly, DENND1A [54], YAP1 [55], ERBB3, and RAB5B [48, 56] are also implicated in PCOS, and have been shown to be involved in endocytosis, cellular trafficking calcium signaling, and the ERBB3 signaling pathway [57–59] As these genes regulate insulin metabolism and hormone production, their involvement may contribute to the higher rate of biochemical and metabolic abnormalities in both PCOS women and their male relatives.