Low proliferation was associated with a decreased risk for RFI events in the univariable analysis (HR = 0.23, 95 %CI: 0.06–0.82, Fig. 6b) and HR = 0.05, (95 %CI: 0.01–0.42) after adjusting for baseline PgR status, tumor size, and age. This evidence concerns the gene PGR and neoplasm.