Recent research suggests that higher ADHD-PRS is associated with reduced resilience to age-related pathological abnormalities, including amyloid beta (Aβ) deposition.21,22 Additionally, in cognitively impaired individuals, higher ADHD-PRS was associated with impaired executive function, elevated tau pathology, as well as hypometabolism in frontal and parietal brain regions.23 Together, these findings suggest that ADHD-PRS may be a relevant factor influencing cognitive decline in older adults. Here, MAPT is linked to attention deficit-hyperactivity disorder.