Furthermore, this study examined whether PRS-cognition associations vary according to baseline levels of plasma biomarkers previously linked to the pathology of AD and related disorders (ADRD) (Aβ [Aβ42], tau phosphorylated at threonine 217 [p-tau217], neurofilament light chain [NfL], and glial fibrillary acidic protein [GFAP]),27 testing the hypothesis that plasma biomarker will moderate the association between ADHD-PRS and cognition. This evidence concerns the gene MAPT and Alzheimer disease.