Additionally, no significant three-way interactions (ADHD-PRS × time × biomarker) were observed after FDR correction (Supplementary Table 6), indicating that baseline levels of plasma Aβ42, p-tau217, NfL, or GFAP levels did not significantly modify the longitudinal association between ADHD-PRS and cognitive trajectories. This evidence concerns the gene NEFL and attention deficit-hyperactivity disorder.