Chromatin immunoprecipitation (ChIP) assays further verified that MYC binds to the promoter region of SKP2 (Fig. 5F), supporting its role as a transcriptional regulator of SKP2. Moreover, ChIP-qPCR analysis in RPL35A-overexpressing and control lung cancer cells indicated that RPL35A overexpression markedly strengthens the recruitment of MYC to the SKP2 promoter (Fig. 5G). This evidence concerns the gene SKP2 and lung cancer.