Notably, aerobic glycolytic activity was significantly suppressed in RPL35A-knockdown lung cancer cells, as demonstrated by reduced glucose uptake, ATP production, and lactate secretion, along with decreased extracellular acidification rate (ECAR) and increased oxygen consumption rate (OCR) (Fig. 4, C–G), indicating a metabolic shift from glycolysis toward oxidative phosphorylation. The gene discussed is RPL35A; the disease is lung cancer.