MYC and lung cancer: Chromatin immunoprecipitation (ChIP) assays further verified that MYC binds to the promoter region of SKP2 (Fig. 5F), supporting its role as a transcriptional regulator of SKP2. Moreover, ChIP-qPCR analysis in RPL35A-overexpressing and control lung cancer cells indicated that RPL35A overexpression markedly strengthens the recruitment of MYC to the SKP2 promoter (Fig. 5G).