KCNB2 and Neurodevelopmental delay: Perhaps most interestingly in the context of the effects of Kv6.1 mutations is the recent report that mutations in Kv2.2 have been identified in a cohort of patients exhibiting variable craniofacial and hand dysmorphisms along with neurodevelopmental delay in some cases, thus there may be some overlapping phenotypic features of Kv2.2 and Kv6.1 variants (29).