PFAS and Hepatic fibrosis: These findings are consistentwith emerging in vivo evidence that PFAS can activateTGF-β/Smad pathways and promote fibrotic tissue remodeling. In addition, epidemiologic data have linkedPFHxS levels to increased odds of liver fibrosis. Since myocardial fibrosis can disrupt electrical conductivityand relaxationraising the risk of arrhythmias and diastolicdysfunction, future study is needed tofurther analyze functional consequence including contractility associatedwith the proteomic changes in ECM organization and metabolism.