Among the variables included in the model, albumin, ferritin, ceruloplasmin, fibrinogen, protein S made a significant contribution to the model and the risk of PPROM was found to be 6.69 times higher in patients with albumin < 36 g/dL, 8.5 times higher in patients with ferritin > 10.39 ng/mL, 4.66 times higher in patients with ceruloplasmin > 0.44 mg/dL, 3.19 times higher in patients with fibrinogen > 3.74 mg/dL, and 3.64 times higher in patients with protein S > 42%. This evidence concerns the gene PROS1 and preterm premature rupture of the membranes.