CXCL1 and preterm premature rupture of the membranes: It was suggested that PP14 might be a new potential biomarker for PPROM and might be converted into a bedside test to rapidly diagnose PPROM.[14] Kahouadji et al found that chemokine C-X-C motif ligand 1 (CX3CL1) level measured in the first trimester was significantly increased in PPROM cases compared with controls and predicted PPROM with a sensitivity of 90% and a specificity of approximately 40%.