PTGS2 and ischemia: The overproduction of prostaglandins causes the narrowing of the blood vessels supplying the uterus, hypercontractility of the uterus (cramps) which leads to ischemia, hypoxia of the uterus, and increased sensitivity of the nerve endings.[32] Molecular docking showed that the strongest binding targets of senkyunolide I, liquiritigenin, and ferulic acid were PTGS2.