In contrast to the classical aspartate aminotransferase-to-alanine aminotransferase ratio (AST/ALT, or De Ritis ratio), the alanine aminotransferase-to-aspartate aminotransferase (ALT/AST) ratio has recently garnered attention as a potential marker for systemic metabolic dysfunction[7,8] – a key pathophysiological feature of OSA. The gene discussed is GPT; the disease is obstructive sleep apnea syndrome.